- 专利标题： Substituted pyrazin-2-amines as inhibitors of ATR kinase
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申请号： US15967110申请日： 2018-04-30
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公开(公告)号： US10479784B2公开(公告)日： 2019-11-19
- 发明人: Jean-Damien Charrier , Steven John Durrant , David Kay , Ronald Marcellus Alphonsus Knegtel , Somhairle MacCormick , Michael Paul Mortimore , Michael Edward O'Donnell , Joanne Pinder , Alistair Rutherford , Anisa Nizarali Virani , Stephen Clinton Young , Philip Michael Reaper
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA Boston
- 代理机构： Dechert LLP
- 代理商 Andrea L. C. Reid
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D403/04 ; C07D413/14 ; C07D401/14 ; C07D403/12 ; C07D409/14 ; C07D413/04 ; C07D413/12 ; C07D417/04 ; C07D417/12 ; C07D471/04 ; C07D241/28 ; C07D401/10 ; C07D403/14 ; C07D405/14 ; C07D417/14 ; C07D401/04 ; C07D403/10 ; C07D405/04 ; C07D405/12 ; C07D409/04 ; A61P35/00
摘要：
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US20190047995A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 公开/授权日：2019-02-14
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