![3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors](/docs/US/2019-11-05/US10464910B2/abs.jpg.600x600.jpg)
- 专利标题： 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
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申请号： US16219669申请日： 2018-12-13
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公开(公告)号： US10464910B2公开(公告)日： 2019-11-05
- 发明人: Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair , David S. Millan , Matthew W. Martin
- 申请人： FORMA Therapeutics, Inc.
- 申请人地址： US MA Watertown
- 专利权人： Forma Therapeutics, Inc.
- 当前专利权人： Forma Therapeutics, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Choate, Hall & Stewart LLP
- 代理商 Michael A. Shinall; Erica M. D'Amato
- 主分类号： A61K31/5513
- IPC分类号： A61K31/5513 ; C07D243/14 ; C07D267/14 ; C07D413/06 ; C07D413/12 ; C07D413/04 ; C07D291/08 ; C07D401/06 ; C07D401/10 ; C07D403/06 ; C07D403/10 ; C07D405/06 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D498/04 ; C07D498/08 ; C07D493/08 ; C07D413/08 ; C07D491/107 ; C07D495/10 ; C07D267/12
![3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors](/abs-image/US/2019/11/05/US10464910B2/abs.jpg.150x150.jpg)
摘要：
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
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