- 专利标题: Modified soluble VEGF receptor-1 genes and vectors for gene therapy
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申请号: US14770991申请日: 2014-03-12
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公开(公告)号: US10385112B2公开(公告)日: 2019-08-20
- 发明人: Richard J. Samulski
- 申请人: Richard J. Samulski , ASKLEPIOS BIOPHARMACEUTICAL, INC.
- 申请人地址: US NC Chapel Hill
- 专利权人: ASKLEPIOS BIOPHARMACEUTICAL, INC.
- 当前专利权人: ASKLEPIOS BIOPHARMACEUTICAL, INC.
- 当前专利权人地址: US NC Chapel Hill
- 代理机构: Olive Law Group, PLLC
- 代理商 Tristan A. Fuierer; Marianne Fuierer
- 国际申请: PCT/US2014/024119 WO 20140312
- 国际公布: WO2014/159546 WO 20141002
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; A61K31/7088 ; A61K35/76 ; C12N15/864 ; C12N15/12 ; C12N7/01 ; C07K14/71 ; C12N15/86
摘要:
The present invention relates to a modified and optimized sFlt1 nucleic acid for inclusion in a virus vector. Use of such vectors can be used for treatment of ocular disorders causing neovascularization, such as macular degeneration.
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