A negative high-voltage generation device with multi-stage selection includes an input, an output, negative charges pumps, electrical switches, and a control device. The negative charge pumps are electrically cascaded between the input and the output and configured to receive zero voltage through the input. The control device turns off at least one of the electrical switches close to the output and turns on the remains of the plurality of electrical switches, and the negative charge pumps and the electrical switches use zero voltage to generate a negative voltage at the output.