A method, information handling system (IHS) and sub-system for enabling booting of the IHS using different operating system configurations. The method includes retrieving, via a processor, a unified extensible firmware interface (UEFI) image from a storage device and initializing at least one UEFI runtime service. The processor determines if a memory map corresponding to the UEFI runtime service defines multiple memory descriptors. In response to determining that the memory map defines multiple memory descriptors, a common memory descriptor is identified. The UEFI runtime service and the corresponding memory map are aligned to the common memory descriptor. The aligned UEFI runtime service and the corresponding memory map are copied to a system memory of the IHS. The operating system is booted, wherein the aligned UEFI runtime service and the corresponding memory map are compatible with operating systems that support single runtime memory descriptors.