- 专利标题: Tamper resistant dosage form comprising inorganic salt
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申请号: US14979888申请日: 2015-12-28
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公开(公告)号: US10300141B2公开(公告)日: 2019-05-28
- 发明人: Lutz Barnscheid
- 申请人: GRÜNENTHAL GMBH
- 申请人地址: DE Aachen
- 专利权人: GRÜNENTHAL GMBH
- 当前专利权人: GRÜNENTHAL GMBH
- 当前专利权人地址: DE Aachen
- 代理机构: Norris McLaughlin, P.A.
- 优先权: EP10009121 20100902
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K47/02 ; A61K47/10 ; A61K31/135 ; A61K31/485
摘要:
A pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, wherein the dosage form contains a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from the matrix comprises at least a time interval during which the release follows zero order kinetics.
公开/授权文献
- US20160106839A1 TAMPER RESISTANT DOSAGE FORM COMPRISING INORGANIC SALT 公开/授权日:2016-04-21
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