Invention Grant
- Patent Title: Heteroaryl substituted aminopyridine compounds
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Application No.: US15738362Application Date: 2016-06-23
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Publication No.: US10294229B2Publication Date: 2019-05-21
- Inventor: Daniel S. Gardner , Joseph B. Santella , Venkatram Reddy Paidi , Hong Wu , John V. Duncia , Satheesh Kesavan Nair , John Hynes , Xiao Zhu
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- Priority: IN1877/DEL/2015 20150624
- International Application: PCT/US2016/038858 WO 20160623
- International Announcement: WO2016/210034 WO 20161229
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61K31/519 ; A61P29/00 ; C07D487/04 ; C07D471/04

Abstract:
Disclosed are compounds of Formula (I) or salts thereof, wherein HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3 d]pyrimidinyl, pyrazolo[3,4 b]pyridinyl, pyrazolo[3,4 d]pyrimidinyl, imidazolo[4,5 b]pyridinyl, and imidazolo[4,5 d]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a nitrogen ring atom in said heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; A is pyrazolyl, imidazolyl, triazolyl, isoxazolyl, oxadiazolyl or dihydroisoxazolyl, each substituted with zero or 1 Ra; and R3, Ra, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.
Public/Granted literature
- US20180186799A1 HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS Public/Granted day:2018-07-05
Information query
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