Invention Grant
- Patent Title: Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties
-
Application No.: US15747818Application Date: 2016-07-28
-
Publication No.: US10287288B2Publication Date: 2019-05-14
- Inventor: Kumar Balashanmuga Pabbisetty , James R. Corte , Andrew K. Dilger , William R. Ewing , Yeheng Zhu
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb
- Current Assignee: Bristol-Myers Squibb
- Current Assignee Address: US NJ Princeton
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- International Application: PCT/US2016/044361 WO 20160728
- International Announcement: WO2017/019819 WO 20170202
- Main IPC: A61K31/16
- IPC: A61K31/16 ; C07C211/33 ; C07D471/04 ; C07D403/12 ; C07D403/14 ; C07D471/06 ; C07D471/20 ; C07D491/20 ; A61P7/02
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20180215755A1 FACTOR XIA MACROCYCLIC INHIBITORS BEARING ALKYL OR CYCLOALKYL P2' MOIETIES Public/Granted day:2018-08-02
Information query
