Among other things, a tire inspection system and method are provided. A radiation source and a detector array are configured to rotate about an axis of rotation. During a first examination of a tire, the tire has a first orientation relative to the axis of rotation, and during a second examination, the tire has a second orientation relative to the axis of rotation. For example, between the first examination and the second examination, the tire is at least one of shifted with respect to the axis of rotation or rotated about a tire rotation axis (e.g., perpendicular to the axis of rotation) to change the orientation of the tire relative to the axis of rotation. In this manner, imagery of the tire may be developed, which can be inspected to identify irregularities, etc., in the tire, for example.