The invention relates to management of programs on a mobile device, and in particular, to a method for activating application programs on a mobile device, and a mobile device based on this method. The method for activating application programs on a mobile device according to an embodiment of the invention comprises the following steps: receiving an application request from a device which is located outside the mobile device; identifying a transmission protocol associated with the application request; and if there are a plurality of safety entities in the mobile device which support the transmission protocol and store application programs associated with the application request, activating an application program associated with the application request in a default safety entity.