The present invention relates to a method for generating a current differential protection supernode based on an electrical topology of a regional distribution network, which belongs to the fields of automation of electrical power systems and relay protection. The present invention generates several supernode differential protection elements, i.e., differential protection objects, and backup differential protection elements by circularly using a depth-first search method according to the inputted branch-node associative data table reflecting the electrical topology of the distribution network. the present invention can accurately located and quickly isolate the faults in the distribution network system, reduce the probability of power cut in the non-fault lines, reduce the coverage of power cut, quickly reconstruct and self-heal the distribution network, and solve the effect of the distributed access system on the distribution network protection.