![Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors](/docs/US/2018-11-27/US10137124B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
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申请号： US15860852申请日： 2018-01-03
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公开(公告)号： US10137124B2公开(公告)日： 2018-11-27
- 发明人: Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. McFaddin , Megan L. McKenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Tony P. Tang , Li Ren
- 申请人： Array BioPharma, Inc.
- 申请人地址： US CO Boulder
- 专利权人： Array BioPharma Inc.
- 当前专利权人： Array BioPharma Inc.
- 当前专利权人地址： US CO Boulder
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/496 ; C07D471/04 ; A61P1/12 ; A61P35/04 ; C07D519/00 ; A61P35/02 ; A61P35/00 ; A61K31/444 ; A61K31/4985 ; A61K31/4995 ; A61K31/506 ; A61K31/5377 ; A61K45/06 ; A61K31/551
![Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors](/abs-image/US/2018/11/27/US10137124B2/abs.jpg.150x150.jpg)
摘要：
Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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