Invention Grant
- Patent Title: Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
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Application No.: US15115615Application Date: 2014-12-11
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Publication No.: US10106829B2Publication Date: 2018-10-23
- Inventor: Shivani Gupta , Sohye Kang
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Gregory M. Zinkl
- International Application: PCT/US2014/069744 WO 20141211
- International Announcement: WO2015/116315 WO 20150806
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N5/10 ; A61K38/14 ; C12N9/10 ; C07K14/705 ; C07K16/00
Abstract:
Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the N-glycosylation pathway.
Public/Granted literature
- US20170166942A1 OVEREXPRESSION OF N-GLYCOSYLATION PATHWAY REGULATORS TO MODULATE GLYCOSYLATION OF RECOMBINANT PROTEINS Public/Granted day:2017-06-15
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