- 专利标题: Diamide macrocycles that are FXIa inhibitors
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申请号: US15508122申请日: 2015-09-03
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公开(公告)号: US10081623B2公开(公告)日: 2018-09-25
- 发明人: Jun Shi , William R. Ewing , Laura Nielsen , Zilun Hu , Mimi L. Quan
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Hong Liu
- 国际申请: PCT/US2015/048212 WO 20150903
- 国际公布: WO2016/036893 WO 20160310
- 主分类号: C07D401/06
- IPC分类号: C07D401/06 ; C07D403/06 ; C07D403/12 ; C07D409/12 ; C07D401/12
摘要:
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- US20170283403A1 DIAMIDE MACROCYCLES THAT ARE FXIA INHIBITORS 公开/授权日:2017-10-05
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