Invention Grant
- Patent Title: Factor XIa inhibitors
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Application No.: US15565748Application Date: 2016-04-11
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Publication No.: US10081617B2Publication Date: 2018-09-25
- Inventor: Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Todaro
- International Application: PCT/US2016/026858 WO 20160411
- International Announcement: WO2016/168098 WO 20161020
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D413/14 ; C07D409/14
Abstract:
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Public/Granted literature
- US20180079743A1 FACTOR XIa INHIBITORS Public/Granted day:2018-03-22
Information query
