The disclosure concerns a wrist and thumb brace with a wrist brace portion for stabilizing a user's wrist, the wrist brace portion having a first aperture adapted for a user's right thumb when the brace is on a user's right hand, and a second aperture adapted for a user's left thumb when the brace is on a user's left hand, the first and second apertures facilitating ambidextrous use of the brace; and a thumb brace portion for stabilizing a user's thumb, the thumb brace portion removably attachable to the wrist brace portion at a first location adjacent to the first aperture when the brace is on a user's right hand, the thumb brace portion removably attachable to the wrist brace portion at a second location adjacent to the second aperture when the brace is on a user's left hand.