- 专利标题： Combination therapy using c-Met inhibitor and IGF-1R inhibitor for c-Met inhibitor resistant cancers
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申请号： US14949041申请日： 2015-11-23
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公开(公告)号： US10064939B2公开(公告)日： 2018-09-04
- 发明人: Seon Hui Shim , Ji Min Lee , Soo Yeon Jung , Woo Sun Kwon , Kyung Ah Kim , Jeong Min Kim , Sun Young Rha , Won Suk Lee
- 申请人： Samsung Electronics Co., Ltd. , Yonsei University, University-Industry Foundation (UIF)
- 申请人地址： KR Suwon-si KR Seoul
- 专利权人： SAMSUNG ELECTRONICS CO., LTD.,YONSEI UNIVERSITY, UNIVERSITY-INDUSTRY FOUNDATION (UIF)
- 当前专利权人： SAMSUNG ELECTRONICS CO., LTD.,YONSEI UNIVERSITY, UNIVERSITY-INDUSTRY FOUNDATION (UIF)
- 当前专利权人地址： KR Suwon-si KR Seoul
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 优先权： KR10-2014-0163792 20141121
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/00 ; C07K16/28 ; A61K31/4985 ; G01N33/574 ; G01N33/74 ; A61K39/00
摘要：
A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met (hereinafter, ‘c-Met inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met inhibitor.
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