A system to program parameters of one or more stages of a transimpedance amplifier (TIA) in an optical sub-assembly (e.g. TO-can package) is disclosed. With this invention, users have the option/flexibility to discretely program any of the stages of the TIA after production of the sub-assembly, i.e. they can still change the TIA settings once the TIA has been installed in a system and the system is in use.