- 专利标题： Pyrrolidine amide compounds as histone demethylase inhibitors
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申请号： US15482584申请日： 2017-04-07
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公开(公告)号： US10022354B2公开(公告)日： 2018-07-17
- 发明人: Kwong Wah Lai , Jun Liang , Birong Zhang , Sharada Labadie , Daniel Ortwine , Peter Dragovich , James Kiefer , Victor S. Gehling , Jean-Christophe Harmange
- 申请人： GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
- 申请人地址： US CA South San Francisco US MA Cambridge
- 专利权人： GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS INC.
- 当前专利权人： GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS INC.
- 当前专利权人地址： US CA South San Francisco US MA Cambridge
- 代理机构： Viksnins Harris Padys Malen LLP
- 优先权： WOPCT/CN2014/088309 20141010
- 主分类号： C07D237/04
- IPC分类号： C07D237/04 ; A61K31/41 ; A61K31/4025 ; C07D207/04
摘要：
The present invention relates to compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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