- 专利标题： Macrocylic pyrimidine derivatives
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申请号： US15300956申请日： 2015-04-02
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公开(公告)号： US10017509B2公开(公告)日： 2018-07-10
- 发明人: Gaston Stanislas Marcella Diels , Bruno Schoentjes , Matthias Luc Aime Versele , Didier Jean-Claude Berthelot , Marc Willems , Marcel Viellevoye , Werner Constant Johan Embrechts , Berthold Wroblowski , Lieven Meerpoel
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 优先权： EP14163443 20140403; EP14183747 20140905
- 国际申请： PCT/EP2015/057399 WO 20150402
- 国际公布： WO2015/150555 WO 20151008
- 主分类号： C07D471/22
- IPC分类号： C07D471/22 ; C07D498/22
摘要：
The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
公开/授权文献
- US20170022202A1 MACROCYLIC PYRIMIDINE DERIVATIVES 公开/授权日：2017-01-26
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