A method for managing a differential memory, in particular a PCM, arranged in two branches, configured to enable differential reading of a first informative content (A) stored in complementary form in the two branches. The method comprises the steps of: storing a second informative content (B) in one of the two branches, preserving the data regarding the first informative content in the other branch; using an auxiliary module (6) for temporarily storing the first informative content, and thus enabling storage of the second informative content without interrupting access in reading to the first informative content; and reading in asymmetrical, or single-ended, mode the first or second informative content.