The utility model discloses a portable nursing treatment box, relates to the field of medical article containers, and provides a box capable of containing waste sharp instruments, medical waste, medicine and common nursing materials. The box comprises a rectangular sharp instrument box, a waste box, a medical supply box and a handle, the waste box and the medical supply box are located on the sameside of the sharp instrument box and are detachably connected with the sharp instrument box through connecting structures to form a rectangular combined box. The waste box and the medical supply boxare detachably connected through a connecting structure to form a small rectangular combined box, the handle is detachably connected with the sharp instrument box at the position close to the small combined box, and the handle and the sharp instrument box can be detachably connected with the middle of the small combined box or the sharp instrument box after being separated. The multifunctional nursing tray can contain waste sharp instruments, medical waste, medicine and common nursing materials. Handle convenient to carry. When a nurse patrols a ward at night, the nurse only needs to hold thenursing box. The sharp instrument box, the waste box and the medical supply box are detachably connected and can be used in a combined or separated mode.