The utility model relates to a light guide laser safety lighting device for a power equipment room. The light guide laser safety lighting device comprises a light generation mechanism, a light guide and a light projection mechanism, the light ray generating mechanism comprises an annular lamp holder arranged on the wall surface through a fixing bolt; a shell is arranged on the outer side of the annular lamp holder; an annular electrode plate is arranged in the annular lamp holder; a power source positive electrode and a power source negative electrode are arranged on the annular electrode plate, a boss-shaped lamp holder radiator is arranged in the wall corresponding to the annular electrode plate, an LED laser lamp bead and a lamp holder electrode spring piece are arranged in the center of the lamp holder radiator, and the power source positive electrode and the power source negative electrode are connected with a power supply mechanism. According to the utility model, a partition wall arrangement method of the LED laser source and the light projector is adopted by the light guide device, so that damp-proof, dust-proof, fire-proof, explosion-proof and electric shock-proof conventional illumination, emergency illumination and energy-saving illumination integration of damp, dust, high voltage, flammability and other high-risk areas is realized.