The utility model discloses an intelligent safety monitoring system for a transformer substation. The monitoring system comprises a main monitoring unit and a plurality of transformer substation monitoring units positioned in the transformer substation, wherein the master monitoring unit is connected with the server, and the server is connected with the plurality of substation monitoring units through the hardware firewall to realize communication between the plurality of substation monitoring units and the master monitoring unit; the transformer substation monitoring unit comprises a PC, anda camera, a two-dimensional code scanner, a PC communication module, a door lock device, an LCD display screen and a single-chip microcomputer communication module which are connected with the PC. ThePC is connected with the handheld terminal through the PC communication module; the PC is connected with the single-chip microcomputer through the single-chip microcomputer communication module. Thesingle-chip microcomputer is connected with a display screen, an alarm module and a signal processing module. The intelligent safety monitoring system for the transformer substation is comprehensive in function, the safety protection performance is improved, the timeliness of accident handling is enhanced, and high-degree automatic control is achieved.