The utility model discloses an ozone disinfection explosive box, including inner box and outer container, the inner box is placed in the outer container, and the outer container includes outer box, outer case lid and the seal ring of cavity design, outer case lid fits outer box through the sealed lid of seal ring on, the outer container cover to be equipped with and bleed and supply the check valve that ozone got into, outer box and outer container are covered and are provided with mutual complete network and come to carry out the buckle of locking to the box, the inner box includes seal ring, box in interior case lid and the transparent, interior case lid fits on the interior box through the sealed lid of seal ring, the inner box is covered and is equipped with the check valve that admits air of bleeding the check valve and supplying ozone to get into, it comes to carry out the buckle of locking to the box to be provided with mutual complete network on interior case lid and the interior box, the internal card check that are used for fixed configuration infusion that are provided with of inner box. This ozone disinfection explosive box, the pollution that causes in the time of effectively preventing to transport the medicine has ensured the aseptic storage transportation of configuration back infusion.