The utility model discloses a hydraulic cylinder type sealing wriggling preventing packer. The hydraulic cylinder type sealing wriggling preventing packer comprises a lower center pipe and a setting rubber cylinder arranged on the outer wall of the lower center pipe in a sleeving mode. A deblocking device arranged on the lower center pipe in a sleeving mode is arranged at the upper end of the setting rubber cylinder. The hydraulic cylinder type sealing wriggling preventing packer further comprises an upper center pipe, an anchoring rubber sleeve and a hydraulic anchoring device, the upper center pipe is axially connected with the lower center pipe through a short bearing joint, the anchoring rubber cylinder is arranged on the outer wall of the upper center pipe in a sleeving mode, and the hydraulic anchoring device is located at the lower end of the anchoring rubber cylinder and arranged on the upper center pipe in a sleeving mode. According to the hydraulic cylinder type sealing wriggling preventing packer, on one hand, the wriggling preventing performance of the packer can be effectively improved, and the service life of the packer is prolonged; on the other hand, the damage to the sleeve is relieved, and the overhauling risk is reduced.