The utility model relates to a clamp with a replaceable clamping head. The clamp comprises a clamp body, a clamping head, an elastic member arranged between the clamp body and the clamping head and two rotating members, wherein the clamp body comprises an upper clamp body and a lower clamp body which is connected with the upper clamp body in a rotating manner; each of the upper clamp body and the lower clamp body comprises a handle part, a head part and a tail part connected between the handle part and the head part; the clamping head comprises an upper clamping head and a lower clamping head which are inserted into the head part of the upper clamp body and the head part of the lower clamp body in a replaceable manner; a clamping plate is arranged at the end, connected with the corresponding head part, of each tail part; the elastic member is clamped onto the two clamping plates of the upper clamp body and the lower clamp body; and the two rotating members are respectively arranged on the sides, near the tail parts, of the handle parts of the upper clamp body and the lower clamp body. The clamp can replace the clamping head as needed, so that the using cost is reduced, the material wastage is decreased, and the functions of no pollution and environmental protection are achieved. In addition, the elastic member can be detachably arranged on the clamp body, so that users can conveniently disassemble and assemble the elastic member.