The utility model discloses a sodium bicarbonate injection flexible package which comprises a first container and a second container, wherein the first container is used for containing sodium bicarbonate injection, and the second container is used for packaging the first container. After the first container is filled with the sodium bicarbonate injection or full of the sodium bicarbonate injection, the first container is vacuumized. The second container is made of gas-barrier materials. Polyethylene or polypropylene is selected to be used as the gas-barrier materials. Due to double packaging, safety of the sodium bicarbonate injection package can be improved, and the requirements for storage and conveyance of the sodium bicarbonate injection are reduced. Vacuum is arranged between the first container and the second container. According to the vacuumized structural design of the first container, due to the fact that air inside the package is removed, diffusible space of carbon dioxide is reduced, the sodium bicarbonate injection is prevented from being decomposed, and quality of the sodium bicarbonate injection flexible package is improved. Due to the fact that the second container is made of the gas-barrier materials, gas inside the package can be prevented from leaking, wherein the gas-barrier materials are the polyethylene or the polypropylene. Due to the structural design, the second container can have higher gas-barrier performance.