The utility model discloses a preloaded type medicine-adding device. The medicine-adding device comprises a medicine-adding barrel, a medical-adding double-needle, a rotary sleeve and a pushing rod. A guide groove is arranged on an inner wall of the top of the medicine-adding barrel along an axial direction, one end of the rotary sleeve extends into the medical-adding barrel, and the other end of the rotary sleeve is a sealed end. A guide spiral through groove is arranged along a cylindrical wall of the rotary sleeve. The pushing rod is arranged inside the rotary sleeve along the axial direction, and a guide block penetrating through the guide spiral through groove and extending into the guide groove is arranged on the pushing rod. In the process of use, by means of a membrane arranged inside a port and the rotary sleeve sealed at the top end, a medicine container and the medicine-adding double-needle are in a sealed state, and absolute asepsis in the process of transport and storage can be achieved. The rotary sleeve is rotated to drive the pushing rod to move down quickly along the guide groove so that the medicine container is pushed, an upper needle tip of the medicine-adding double-needle is used to pierce a sealing plug on the medicine container and a lower needle tip of the medicine-adding double-needle is used to pierce the membrane inside the port, and therefore the medicine container and an infusion container are communicated instantly, and an entire course is all in asepsis butt joint. Thus, asepsis sealing of the entire course of transportation, storage, butt joint, medicine-mix and infusion can be achieved.