The single weaving shaft production method for cotton and artificial silk end-to-end fabrics comprises a) Ply two yarns of artificial silk, casing an elastic nylon sheath on the cylinder with two times length of the cylinder, half of the sheath inserted into the cylinder, spreading the plied yarn of artificial silk on the cylinder to dye and dry, extending the elastic nylon sheath inside the cylinder outward to cover the outer layer artificial silk, and setting the machine whose yarn roll is driven directly by a motor. b) Spread the cotton yarn on the cylinder for dyeing, rewinding and plying. c)After the baking house of the slasher, adds plying frame, with the ply yarn of artificial silk rested on the frame, reeling off the existing cotton yarn from the frame, combining with artificial silk after box sizing and drying, directly rolling it on the weaving shaft through adjustable reed lattice. It can reduce unnecessary investment, with the cloth even in surface and the operation easy to handle.