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CN1950355B 制备3-(3,4-亚甲基二氧基苯基)-2-甲基丙醛的方法 失效 - 权利终止

制备3-(3,4-亚甲基二氧基苯基)-2-甲基丙醛的方法
摘要：
本发明公开了用于制备3-(3，4-亚甲基二氧基苯基)-2-甲基丙醛(I)的方法，该方法包括以下步骤：a)使5-丙醛基-1，3-苯并间二氧杂环戊烯(III)与威尔斯麦尔试剂(II)在0℃-40℃之间的温度反应，然后在无质子无极性溶剂中用碱处理反应混合物，以获得式(IV)的不饱和氯醛；b)在载体型多相催化剂存在的情况下，催化剂包含选自钯、铂、铑、钌的金属，在有机碱的存在下或在有机碱与无机碱的混合物存在的情况下，使前面步骤中获得的结构式(IV)的不饱和氯醛与氢反应。
摘要（英）：

The invention discloes a process for the preparation of 3-(3,4-methylenedioxyphenyl)-2-methylpropanal (I) comprising the following steps: a) reacting 5-propanoyl-1,3- benzodioxol (III) with the Vilsmeier reagent at temperatures ranging between 0 DEG and 40 DEG C and subsequently treating of the reaction mixture with a base in aprotic apolar solvent to obtain the unsaturated chloroaldehyde of formula (IV); b) reacting the unsaturated chloroaldehyde of formula (IV), obtained in the previous step, with hydrogen in the presence of a supported heterogeneous catalyst containing a metal chosen amongst Pd, Pt, Rh, Ru in the presence of an organic base or of a mixture of an organic and inorganic base.

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