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CN1864743A 用于治疗胰岛素抗性和以胰岛素抗性为特征的疾病状态的方法 无效 - 撤回

用于治疗胰岛素抗性和以胰岛素抗性为特征的疾病状态的方法
Abstract:
本文公开了MINOR和TR3基因是随人和各种完全表征的动物模型中的胰岛素抗性和2型糖尿病而变化的差异表达的胰岛素应答基因。本发明公开的内容表明MINOR和TR3在胰岛素抗性中有功能性作用。因此，MINOR和TR3是用于抗击胰岛素抗性和/或以胰岛素抗性为特征的疾病状态或病症的有吸引力的和新的治疗靶点。本文也公开了胰岛素抗性和以胰岛素抗性为特征的疾病状态和病症，包括II型糖尿病，与MINOR和TR3基因表达的相关性。本文还公开了用于治疗和/或预防胰岛素抗性和以胰岛素抗性为特征的疾病状态和病症的诊断、治疗和预防的方法。
Abstract(English):

The MINOR and TR3 genes are disclosed to be insulin responsive genes differentially expressed as a function of insulin resistance and Type 2 Diabetes in humans and a variety of well characterized animal models. The present disclosure shows that MINOR and TR3 have a functional role in insulin resistance. Therefore, MINOR and TR3 are attractive and novel therapeutic targets for combating insulin resistance and/or disease states and conditions characterized by insulin resistance. Correlation of insulin resistance and disease states and conditions characterized by insulin resistance, including Type II diabetes, with MINOR and TR3 gene expression are also disclosed. Methods of diagnosis, treatment and prevention are likewise disclosed for the treatment and/or prevention of insulin resistance and disease states or conditions characterized by insulin resistance.

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