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发明授权
CN1863558B 具有向核内转移能力的聚精氨酸修饰的脂质体 失效 - 权利终止

具有向核内转移能力的聚精氨酸修饰的脂质体
摘要：
本发明的目的在于提供具有向细胞内和核内转移特性的脂质体，为了达到这个目的，提供在表面带有含连续数个精氨酸残基的肽的脂质体，具体来说，上述肽预先用疏水性基团或疏水性化合物修饰，上述疏水性基团或疏水性化合物插入脂质双层中，而上述肽露出上述脂质双层的脂质体。
摘要（英）：

With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.

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