The invention relates to a pharmaceutical composition for treating rheumatoid diseases and process for preparation, wherein the pharmaceutical composition comprises the following raw materials (by weight ratio): long-noded pit viper 1-20 parts, buthus martensi kirsch 0.5-15 parts, hornet nest 1-35 parts, Chinese pyrola herb 1-45 parts, Christmas cactus 1-45 parts, hairy birthwort 1-45 parts, licorice root 1-20 parts, and dung beetle 0.5-15 parts. The pharmaceutical composition can be made into any proper oral preparation through conventional methods.