The invention discloses the manufacturing method of liquid-solid non PVC film big transfusion and multiple bags, comprising film separation, setting pipe, vacuum sucking film, undrawing film, heat seal and cutting perimeter. The method has the advantages that the solid chamber non PVC film can't adhibit. It is suit to the procedure of liquid-solid non PVC film big transfusion and multiple bags, and overcomes the defect of current technology.