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CN1587251A 从紫锥菊制备菊苣酸的方法 失效 - 权利终止

从紫锥菊制备菊苣酸的方法
摘要：
本发明从紫锥菊制备菊苣酸的方法，该方法以紫锥菊为原料，包括有机溶剂提取、酸化、溶剂萃取、树脂分离、溶剂结晶等工艺过程。在有机溶剂提取过程中采用乙醇水溶液作有机溶剂提取制备菊苣酸水溶液，乙醇水溶液的质量浓度为30～50％，紫锥菊与乙醇溶液的固液比为1∶4～10，提取温度为70℃～90℃；将菊苣酸水溶液进行酸化处理，用酸溶液调节菊苣酸水溶液的pH≤3；在分离提纯过程中采用大孔吸附树脂分离，用去离子水洗涤，乙醇水溶液洗脱，浓缩得到菊苣酸粗产品；将菊苣酸粗产品溶于水中，用酸溶液调节菊苣酸水溶液的pH＝1～3，经冷却结晶得到纯度在96％以上的菊苣酸精产品。是一种适用于工业生产制备高纯度苣菊酸的方法。
摘要（英）：

The process of preparing chicoric acid from echinacea purpurea includes organic solvent extraction, acidification, solvent extraction, resin separation, crystal in solvent and other technological steps. During organic solvent extraction, water solution of ethanol of 30-50 wt% concentration and in the amount of 4-10 times echinacea purpurea weight is used as the organic solvent to prepare water solution of chicoric acid at the temperature of 70-90 deg.c. During the acidification of water solution of chicoric acid, the pH value of the water solution of chicoric acid is regulated with acid solution to not greater than 3. The separation and purification process includes separation with macroporous resin, washing with deionized water, elution with ethanol aqua, concentration to obtain coarse chicoric acid product, dissolving the coarse chicoric acid product in water, pH regulation of the chicoric acid aqua to 1-3 and cooling to crystallize and to obtain chicoric acid product with purity over 96 %.

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