A configuration method for key parameters of an AGC master station in a high-proportion hydropower area comprises the following steps: a, establishing a regional power grid whole-process simulation model; b, acquiring a natural frequency characteristic coefficient of the regional power grid by a simulation means; c, establishing a common disturbance set of the power grid; d, setting a configuration scheme applicability evaluation index; e, forming a group of frequency deviation coefficients; f, setting proportional gains of different control areas; g, setting a normal area threshold, a secondary emergency area threshold and an emergency area threshold of the system; and h, performing rationality evaluation on the frequency deviation coefficient and the proportional gain, returning to the step e if the requirements are not met, and taking the result as a final configuration scheme if the requirements are met. On the basis of establishing a regional power grid whole-process simulation model, configuration of key parameters of the AGC master station in the high-proportion hydropower area is realized by means of simulation. Compared with a traditional method, the method can improve thefrequency quality of the power grid and ensure safe and economic operation of the power grid.