The invention relates to a use method of a dust removal device utilizing natural airflow ventilation in cotton ginning production. The method is characterized in that: the device includes a multi-layer ginning workshop, a windward pipe, a narrow vertical shaft, a horizontal air duct, water spray nozzles, an exhaust pipe and a curved-shaped water tank; according to the use method, when air flows through the curved-shaped water tank, the pressure decreases and air in the exhaust pipe is sucked from the lower part to the upper part and flows out; on the other hand, when the air flows in from thewindward pipe and passes through the narrow vertical shaft, the pressure decreases as the channel becomes narrower, so that dust in the multi-layer ginning workshop is sucked into the narrow verticalshaft, and enters the horizontal air duct, and the dust is covered by water mist sprayed by the water spray nozzles, wherein the dust adhered to water and the water sprayed by the water spray nozzlesenter the sewer and flow downward from a floating gate into an open caisson; a small amount of dust to which water is not attached enters the exhaust pipe, hits the bottom surface of the curved-shapedwater tank, and is stuck by a dust-absorbing wet cloth; then, clean air after dust removal flows out from the exhaust port. The dust removal device does not require power and is noiseless.