The invention discloses a simvastatin suspension emulsion, and a preparation method and application thereof. Components include simvastatin, a surfactant, an emulsifier, a slow-release agent, an antioxidant, a preservative and the balance of water for injection. According to pharmaceutical properties of the simvastatin and a preparation process of microcapsule, the preparation method is as below:simvastatin is first prepared into a microcapsule structure with a slow-release function, and then the microcapsule structure is mixed with other aids to prepare the suspension emulsion. The surfactant and emulsifier endow the simvastatin suspension emulsion with the advantages of both suspension and emulsion, and improve an effective dosage of the simvastatin in a carrier; the simvastatin reachesa target organ quickly after intramuscular injection, an effective blood concentration of the target organ is maintained for a long time, and the slow-release function of the microcapsule structure extends the half-life of the drug, and improves the bioavailability of the drug, so as to reduce the times of administration and reduce side effects of the drug; and the most important aspect is that the simvastatin suspension emulsion has no antibiotic residue, and has a broad clinical application prospect.