The invention discloses an unmanned aerial vehicle matched transportation box applied to the express transportation business. The unmanned aerial vehicle matched transportation box comprises a transportation box body; the transportation box body is internally provided with a package chamber, wherein the package chamber comprises a forward opening and can be used for storing express packages; the upper side of the package chamber is provided with a storage chamber in a communication manner; the storage chamber is internally provided with a roller shutter which is used for closing or opening thepackage chamber; the upper side of the storage chamber is provided with two bilaterally-symmetric driven chambers of which the openings are upward; and the inner wall of each driven chamber is provided with a slider which can slide up and down. The unmanned aerial vehicle matched transportation box disclosed by the invention can be matched with a civil small-size unmanned aerial vehicle for use,can enhance the transportation capacity of the express delivery industry in an air transportation way, increases the transportation speed, can be used for directly sending expresses to balconies of high-building residents by virtue of air transportation and can realize higher relevance between the overall unmanned aerial vehicle and the transportation box and the relevance between the transportation box and the express packages because of higher linkage inside the transportation box.