The invention belongs to the technical field of cold chain logistics transport refrigeration equipment, cold storage and refrigeration, and particularly discloses a whole-process intelligent monitoring constant-temperature cold chain logistics box. The whole-process intelligent monitoring constant-temperature cold chain logistics box comprises a fixing frame, a box cover and an intelligent controlsystem, the box cover is mounted at the top of the fixing frame and used for sealing the top of the fixing frame, and the intelligent control system is mounted on the fixing frame and used for providing energy for the fixing frame. As for a preferred scheme of the whole-process intelligent monitoring constant-temperature cold chain logistics box, the fixing frame comprises a box body, a coolant chamber, a storage chamber and heat dissipating fins, the coolant chamber is located in the left side of the inner wall of the box body and used for cold storing, and the storage chamber is located inthe right side in the box body and used for storing. According to the whole-process intelligent monitoring constant-temperature cold chain logistics box, the comprehensive effects of high-quality distribution, whole-process monitoring, low-energy-consumption operation, and long-endurance transporting are achieved.