The invention introduces a multi-body highway informatization management system and a use method thereof, and belongs to the technical field of highway management, the multi-body highway informatization management system comprises a basic data management module, an electronic approval module, a traffic facility maintenance module and a data sharing library which are respectively connected and intercommunicated with a decision processing module, and the basic data management module is connected with the electronic approval module; the basic data management module is also connected and intercommunicated with the data sharing library; the decision processing module comprises a daily management module and an emergency command module; and the basic data management module comprises the followingmodules: an electronic tag data management module, a datamation coding module and an electronic map management module. When emergency situations such as traffic accidents occur, the specific positions of various rescue vehicles can be clearly seen through the emergency command module, the vehicle closest to the accident occurrence place is quickly gathered to go to the scene for rescue at the first time, and precious time is gained for reducing the life and property of people.