The invention discloses a vacuum adsorption base and a display panel binding device. The vacuum adsorption base comprises a carrying table and a plurality of adjusting pieces, wherein the carrying table comprises a first surface used for bearing a to-be-vacuum-adsorbed assembly and a second surface opposite to the first surface, and the carrying table comprises a vacuumizing hole connected with anexternal vacuum source and a vacuum cavity communicating with the vacuumizing hole; and the multiple adjusting pieces are arranged on the carrying table in a telescopic mode so as to adapt to the form of the to-be-vacuum-adsorbed assembly. According to the vacuum adsorption base and the display panel binding equipment, the same vacuum adsorption base can be adopted to carry out vacuum adsorptionoperation on different versions of to-be-vacuum-adsorbed assemblies, so that the production cost is saved, the problem of temporarily changing the to-be-vacuum-adsorbed assemblies can be solved, the realization of the vacuum adsorption operation is guaranteed, and then the subsequent operation can be ensured to be carried out smoothly.