The present invention discloses a preparation method of a medicinally and edibly homogeneous health-care product. The preparation method comprises the following processes: preparation of Chinese yam powder, preparation of a walnut extract, preparation of red jujube powder and preparation of auxiliary materials. The preparation method comprises the following steps: 20 parts-30 parts of Chinese yampowder, 5 parts-10 parts of a walnut extract, 10 parts-20 parts of red jujube powder, 20 parts-50 parts of auxiliary materials and an appropriate amount of water are mixed evenly, a wet material is prepared, the wet material is pressed into tablets, then thin tables are dried in an oven, and finally vacuum packaging is conducted to obtain the health-care product. During preparation processes of the health-care product, most of mucus proteins in the Chinese yams are removed and potential allergy risks caused by allergens in the health-care product are reduced; and secondly, a technology of supercritical extraction of walnut oil is optimized, an entrainer is modified, action of the entrainer reduces solubility of saturated fatty acids in a solvent supercritical system and thus reduces content of saturated fatty acids in the health-care product, which is beneficial to health.