The invention discloses an ethylene-propylene-diene monomer-based electric wire cable rubber protection sheath and a preparation method thereof and belongs to the technical field of preparation of rubber products. The protection sheath comprises the following raw materials in parts by mass: an ethylene-propylene-diene monomer, white carbon black, calcium carbonate, PEG-4000 (polyethylene glycol-4000), an anti-aging agent 4010NA, an anti-aging agent RD, an anti-aging agent MB, an anti-aging agent 264, paraffin, sulfur, silicon 69, an accelerant M, an accelerant CZ, an accelerant EZ, an accelerant BZ, an accelerant TMTD (tetramethyl thiuram disulfide), zinc oxide, stearic acid, a petroleum resin, paroline, titanium dioxide and a light resistant agent UV-9. The preparation method disclosed bythe invention comprises the following steps: firstly, weighing the components, and preparing premixes of large and small materials; performing rubber material smelting; performing cure characteristiccurve testing; and finally performing vulcanization so as to obtain a product. The ethylene-propylene-diene monomer-based electric wire cable rubber protection sheath disclosed by the invention is low in cost, simple in preparation process, excellent in performance and applicable to popularization and application.