The invention discloses a method for catalyzing selective hydrogenation of 1, 3-butadiene by using a NiPdRu catalyst, and belongs to the technical field of chemistry and chemical engineering. The method comprises the following steps: putting the NiPdRu catalyst into a tubular reactor, heating a catalyst bed to a certain temperature, introducing a mixed gas of the 1, 3-butadiene and hydrogen into the reactor, and carrying out a reaction at a certain pressure and airspeed. Different from the traditional supported catalyst, the high-activity and high-stability supported NiPdRu catalyst for selective hydrogenation of the 1, 3-butadiene can be prepared by adjusting the contents of metal nickel, palladium and ruthenium and the content of TiO2@C in the catalyst according to the invention. When the catalyst is used for selective hydrogenation reaction of the 1, 3-butadiene, the content of the 1, 3-butadiene in the product is lower than 595ppb, the content of butane is lower than 1.2%, and thecatalyst still keeps good catalytic activity after continuous operation for 150h.