Disclosed is a tool dynamic self-adaptive compensation method based on eccentric difference control. The method comprises the following steps of 1, selecting a measuring point according to a tool pathmachining model of a reference profile; 2, determining an eccentric angle of a coordinate system when a cutter passes through a point position relative to a coordinate system where a part is located,specifically, a change amount conversion formula under a two-dimensional coordinate system is shown in the specification; 3, based on the information of a tool coordinate point, calculating an eccentric difference of the point relative to the theoretical contour model in a tool coordinate system, and adding an adjustment amount made for the eccentric difference to obtain a difference value of thepoint (please refer to the specification); 4, selecting a machining state of the point before the cutter is added to obtain that an overall eccentric difference is (please refer to the specification); 5, respectively solving a derivative function on each variable according to a matrix derivation principle and being equal to 0, specifically, as for the function, please refer to the specification;and 6, adjusting a path according to a compensation of the cutter in each direction. Compared with the prior art, the tool dynamic self-adaptive compensation method based on eccentric difference control effectively eliminates the integral error of a curved surface caused by a local deviation, is capable of dynamically adjusting a compensation value in real time, and guarantees the integral uniformity of part machining.