The invention discloses starch-based melt-spinning resin and application thereof. The starch-based melt-spinning resin is prepared from, by weight, 15-65 parts of starch, 35-85 parts of PVA, 20-45 parts of a plasticizer, 1.0-2.5 parts of a decomposition inhibitor, 0.5-5 parts of a fluorocarbon active agent and 1.0-10 parts of a processing aid. By modifying a starch PVA system, the melting point and decomposition point distance of the starch PVA system is increased, the initial thermal decomposition temperature is increased, the melt index is increased, the migration of a small molecule plasticizer is inhibited, and the obtained starch-based melt-spinning resin has complete biodegradation characteristics. The resin is used for preparing a non-woven fabric through a melt-spinning method, theprocess is simple, the equipment investment is low, no organic solvent nor coagulation bath is used, energy is saved, and environmental pollution caused by three wastes does not occur.