The invention discloses a transformer substation full-stop load transfer and supply method. The method comprises the following steps of: S1, after faults are generated, processing each feeder of a power failure transformer substation, identifying that a feeder path is a single path or multiple paths, and determining the contact relation between main transformers; S2, collecting initialization calculation parameters, and solving an optimal primary transfer scheme by employing a genetic algorithm; S3, verifying whether the main transformer substation after the transfer meets the constraint condition of the main transformer or not, if there is a transformer substation which cannot meet the main transformer constraint, considering secondary transfer and supply; S4, determining the maximum transferable load of the weak links and the overload capacity thereof, if the maximum transferable load is smaller, modifying the load rate of the weak links after secondary transfer and supply, and performing solution of a primary transfer mathematical model; and S5, according to the optimal scheme, solving the fault recovery rate of each fault circuit. The transformer substation full-stop load transfer and supply method can reduce the recovery time of the load while effectively improving the transfer and supply success rate of the load so as to reduce the power failure loss of the load caused bythe transformer substation.