The invention discloses an anti-blockage regulation valve. The anti-blockage regulation valve comprises a valve seat and a valve element, wherein the valve seat is provided with a mounting channel which is through in the thickness direction of the valve seat; the inner wall face of the valve seat is provided with at least one scraping knife part protruding inwards in the radial direction of the valve seat; at least one part of the upper surface of each scraping knife part forms a first bevel obliquely extending relative to the horizontal direction; at least one part of the lower surface of each scraping knife part forms a second bevel obliquely extending relative to the horizontal direction; the valve element is a V-shaped unbalanced valve element; the valve element is arranged in the mounting channel and can move in the axial direction of the mounting channel; at least one part of the inner wall face of each scraping knife part abuts against the outer wall face of the valve element toscrape off impurities on the outer wall face of the valve element when the valve element moves. The anti-blockage regulation valve provided by the invention is simple in structure, convenient to disassemble and assemble, not prone to blockage and suitable for the working conditions of easy crystallization, blockage and particles.